DAO
Decentralized Autonomous Organization. A group whose treasury and decisions are controlled by smart contracts and token-holder votes. Outcomes range from genuinely organized to barely-functional Discord.
DeFi
Decentralized Finance. Lending, trading, derivatives, and other financial primitives built as open smart contracts. Composable, transparent, and routinely exploited.
DEX
Decentralized Exchange. A trading venue that runs as smart contracts, with no central operator holding user funds. Uniswap, Curve, dYdX.
Difficulty
How hard the proof-of-work puzzle is. Bitcoin retargets every 2016 blocks (about two weeks) so blocks keep arriving every ~10 minutes regardless of how much hashrate is online.